Annihilation

Annihilation can't be countered.
You choose two legendary creatures, and then
each player exiles all other permanents they
control. Exile all cards in hands, all cards in
graveyards, and all libraries.
Light: This is it, Misa. The end of the world.
Misa: I'm glad we're together, Light. Aren't you?
Light: I suppose...
Misa: Oh wow! Look at the pretty colors!