Kalyvex, Scion of Kozilek

Annihilator 3, Ward - Pay 6 life.
At the beginning of each upkeep, each opponent
must sacrifice a permanent.
If an opponent has no permanents left in play,
they lose the game.
Kalyvex will warp reality, taking away the comforts
of truth and destroying everything you care about, like
the creature he represents.