Thanos

{b}: Target creature gets -2/-2 until end of turn.
{w}: Thanos gains lifelink until end of turn.
{u}: Use scry 3. Draw a card.
{g}: Create two 2/2 colorless Son of Thanos
creature tokens with first strike.
{r}: Thanos gets +3/+0 and trample until end of
turn.
{b}{w}{u}{g}{r}: Exile half of the creatures.
They can't be regenerated.