The Reality Stone

({p/c} can be paid with either {3} or 5 life.)
Creatures your opponents control don't regenerate toughness.
Creatures you control have infect. (They do damage to creatures in the form of -1/-1 counters, and damage to players in the form of poison counters.)
Enchantments you control have shroud.
Behold the total destruction of what's real!