The Soul Stone

In order to get the soul stone, sacrifice a "Gamora, Trained Assassin", or a "Romanoff, Black Widow"
card while you have a "Red Skull, Stonekeeper"
Token and a "Vormir, Dominion of Death" card.
If you sacrifice "Romanoff, Black Widow", obtain "Clint's Depression" from your discard pile. If "Thanos, Mad Titan" uses this, remove 20 loyalty counters from a planeswalker.